Structural and functional correlate of signal conduction velocity in the human brain

Antoine Lutti, LREN, Department of Clinical Neuroscience CHUV

Advanced magnetic resonance imaging techniques provide in-vivo measures of the g-ratio, the ratio of the inner and outer diameter of myelinated fibers. These measures allow specific inference of microscopic brain tissue change in healthy and pathological conditions. Here we investigate how well MRI-based g-ratio measurements along specific fiber tracts can inform about signal conduction velocity. To this aim, we design an event related potentials study in the same participants undergoing the MRI measurements in order to estimate the time-delay along typical tracts of signal transmission.